Insulin, anaerobiosis, and phlorizin in entry of d-galactose into skeletal muscle

¹ Department of Physiology, University of Rochester Medical Center, Rochester, New York

In the eviscerate-nephrectomized rat the increase in the galactose space seen after insulin was significantly prevented by phlorizin in concentrations which by themselves were without effect on this function. Similarly, the d-galactose uptake by rat diaphragm was increased by insulin, and this effect was also significantly reduced by phlorizin in concentrations that had no effect on d-galactose uptake in the absence of insulin. The increased uptake of d-galactose by the rat diaphragm incubated in nitrogen was also significantly reduced in the presence of phlorizin.