Glomerular filtration in the rat after ureteral ligation

¹ Department of Biochemistry and Nutrition, The University of Texas Medical Branch, Galveston, Texas

The rate of glomerular filtration in rats with ligated ureters was found to depend on the length of time after establishment of obstruction. About 4% of plasma passing through the kidney was filtered after 30 min of total ligation, compared with nearly 20% in control rats. The rate progressively increased thereafter, exceeding half the control rate within 4 hr, but undergoing no further important changes up to 6 hr after ureteral obstruction. Intravenously administered inulin diminished rapidly in plasma of control rats, less rapidly in rats with ureters ligated 4 hr prior to the injection, and most slowly in nephrectomized rats, the relative concentrations 3 hr after injection being 1:3:8, respectively. Inulin recoveries were essentially complete in all cases. This supports the conclusion that concentration of inulin in plasma at termination of the experiments was inversely and solely related to efficiency of glomerular filtration. The apparent 3-hr inulin space for these special conditions, derived from measurements on nephrectomized rats, was 17.3 ml/100 g total body wt. in rats fasted for 24 hr with free access to water.

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