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Am J Physiol 202: 545-546, 1962;
0002-9513/62 $5.00
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Effect of acetoacetate on blood coagulation in rabbits and its prevention

M. C. Nath 1 and D. M. Brahmankar 1

1 University Department of Biochemistry, Nagpur, India

The effect of Na-acetoacetate injections on blood coagulation factors was studied. No change in blood coagulation factors occurred in 4 weeks, but continued treatment of acetoacetate for 8 weeks was found to cause hastening of blood coagulation. The hydrolyzed product of glucose cycloacetoacetate was found to prevent the acceleration of blood coagulation in acetoacetate-treated animals.

Submitted on September 25, 1961






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