| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Research Laboratories, Department of Psychiatry, University of Illinois College of Medicine, Chicago, Illinois
The main purpose of the present work was to study in detail the outflux of P32 from excitable tissues accompanying membrane depolarization or electrical excitation. With the use of P32 as a tracer, it has been demonstrated that orthophosphate and a number of organic phosphates slowly diffuse out of nerve and muscle even after 2 hr of exposure to Ringer's solution. On exposure to calcium-free or potassium-rich media, or during electrical excitation, there is a considerable increase in the outflux of a number of acid-soluble phosphates, particularly orthophosphate and adenosinetriphosphate. Further evidence in support of this concept was based on the fact that the radioactive specific activity of the diffusible phosphates was greater than the internal phosphates of excitable tissues. Since all these procedures are known to result in depolarization of excitable tissues, there was reason to believe that the outflux of muscle phosphates was somehow related to the physicochemical changes associated with membrane depolarization. The changes in the outflux of P32 from the muscle or nerve, either stimulated or soaked in calcium-free or potassium-rich media, appear to be related to the changes in the membrane potential.
Submitted on August 14, 1961
This article has been cited by other articles:
|
|
 |
|
  S. Godecke, T. Stumpe, H. Schiller, H.-J. Schnittler, and J. Schrader Do rat cardiac myocytes release ATP on contraction? Am J Physiol Cell Physiol, September 1, 2005; 289(3): C609 - C616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Dutta, R. Z. Sabirov, H. Uramoto, and Y. Okada Role of ATP-conductive anion channel in ATP release from neonatal rat cardiomyocytes in ischaemic or hypoxic conditions J. Physiol., September 15, 2004; 559(3): 799 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Vassort Adenosine 5'-Triphosphate: a P2-Purinergic Agonist in the Myocardium Physiol Rev, April 1, 2001; 81(2): 767 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Hong and C. C. Chang Evaluation of Intrinsic Modulation of Synaptic Transmission by ATP in Mouse Fast Twitch Muscle J Neurophysiol, November 1, 1998; 80(5): 2550 - 2558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Poisner and W. W. Douglas Adenosine Triphosphate and Adenosine Triphosphatase in Hormone-Containing Granules of Posterior Pituitary Gland Science, April 12, 1968; 160(3824): 203 - 204. [Abstract] [PDF]
|
|
|
|
|
|
A. S. Kuperman, M. Okamoto, A. M. Beyer, and W. A. Volpert Procaine Action: Antagonism by Adenosine Triphosphate and Other Nucleotides Science, June 5, 1964; 144(3623): 1222 - 1223. [Abstract] [PDF]
|
|
|
|
|
|
L. G. Abood and I. Koyama Phosphate Incorporation in Desheathed Nerves: Effects of Potassium and Calcium Ions Science, September 27, 1963; 141(3587): 1277 - 1278. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
