Effect of Triton WR-1339 on absorption and fate of I¹³¹ oleic acid in normal guinea pigs

¹ Tuberculosis and Radioisotope Research Laboratories, Veterans Administration Hospital, Washington, D.C.

The influence of Triton WR-1339 on the absorption and tissue assimilation of orally administered I¹³¹ oleic acid was studied in normal guinea pigs. No significant difference was observed in either the plasma or liver radioactivity. However, the amount of radioactivity precipitated with plasma protein was significantly higher in Triton-treated animals. Extraction of the protein precipitates with lipid solvents demonstrated that the precipitated radioactivity was associated with lipid. The mechanism by which Triton induced increased serum levels of fatty acids was discussed in view of these findings.