Hepatic production of serum alpha₂ and beta globulins in rats after injury

¹ Department of Physiological Chemistry and Department of Anatomy, Wayne State University College of Medicine, Detroit, Michigan

Changes produced in the distribution of serum glycoproteins in rats following partial hepatectomy and chemical hepatic necrosis were studied, using paper electrophoresis. Elevations in concentrations of the ₂ and ß-globulins usually resulting from injury were abolished by partial hepatectomy. Chemical hepatic necrosis, carbon tetrachloride, reduced the control level of the ₂ globulins in serum but did not abolish the response usually elicited by sponge implantation. The concentration of ß-globulins was elevated by treatment with carbon tetrachloride. Subsequent trauma by sponge implantation caused a further increase in these proteins. It is concluded that the liver is a major site of synthesis of the ₂ and ß-globulins which are produced in response to trauma.

Note:
With the Technical Assistance of Marietta Munoz