Effect of acetazolamide on dog parotid saliva

¹ Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland

Canine parotid saliva was obtained at varying secretory rates by the stimulation of the postganglionic parasympathetic nerve. Analysis revealed this secretion to have a CO₂ content of about 20–30 mEq/liter at low rates of salivary flow to 50– 60 mEq/liter at high flow rates. After the intravenous administration of acetazolamide, the CO₂ content at high flow did not rise much above those levels attained at low secretory rates. Acetazolamide also caused decrease of sodium concentration and an increase in chloride concentration at high rates of secretion.