Utilization of C¹⁴-labeled cottonseed oil emulsion by normal and thermally injured rats

¹ U. S. Army Surgical Research Unit, Brooke Army Medical Center, Fort Sam Houston, Texas

The rates of oxidation, blood clearance, and deposition of a C¹⁴-labeled cottonseed oil emulsion (Lipomul I.V.) injected intravenously into normal, burned, and fasted rats have been determined. Standard thermal injury with varying postburn intervals did not change the rate of oxidation from normal, while moderate fasting of unburned rats produced slightly elevated rates. Small increases above normal clearance times were induced in both burned and moderately fasted animals. A significant depression from normal rates of deposition was observed in fasted rats, while the marked decrease in deposition seen in the early postburn course returned to normal levels in about 3 weeks. Animals pair-fed against one group of burned mates showed essentially normal fat deposition.

Note:
With the Technical Assistance of Ruth Deadrick, George Dean, and Leonard H. Driscoll