Cerebrospinal fluid iodide

¹ Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis, Missouri

In vitro preparations of rabbit choroid plexus accumulated I¹³¹ to a concentration 20–30 times the media. The accumulation was temperature dependent and was blocked by metabolic inhibitors. It could also be saturated with iodide, and was inhibited by perchlorate, fluoroborate, and related anions. In vivo the low 4-hr steady state concentration (1.6% of plasma) of trace doses of I¹³¹ in the rabbit cerebrospinal fluid was increased (to 40% of plasma) by the systemic administration of iodide or perchlorate. The results resembled qualitatively those obtained in the vitreous and aqueous humors of the same animals and suggested an active transport of iodide out of the cerebrospinal fluid, much as postulated previously for ocular fluids.

Note:
With the Technical Assistance of Tommie Tracy and Carol Fritz

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				R. D. Berlin Purines: Active Transport by Isolated Choroid Plexus Science, March 14, 1969; 163(3872): 1194 - 1195. [Abstract] [PDF]