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Am J Physiol 201: 1131-1133, 1961;
0002-9513/61 $5.00
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Effect of lysergic acid diethylamide and its brom analogue on arterial hypertension in the rat

Stephen Sugaar 1, George H. Fried 1, John Kalberer 1, and William Antopol 1

1 Joseph and Helen Yeamans Levy Foundation Laboratories, Beth Israel Hospital, New York City

Subcutaneous administration of d-lysergic acid diethylamide (LSD) or 2-brom-d-lysergic acid diethylamide (BOL) markedly lowered the blood pressure of renal hypertensive rats. Drops of 50–120 mm Hg below established hypertensive blood pressure levels occurred within 48 hr after drug administration. For the following 10–14 days the pressure fluctuated, and then returned to original hypertensive levels. In normotensive control rats fluctuations of lesser absolute magnitude occurred within normal blood pressure ranges.

Submitted on October 25, 1960






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