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Am J Physiol 201: 1123-1125, 1961;
0002-9513/61 $5.00
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Blood pressure lowering action of adenosine diphosphate and related compounds

David B. Gordon 1 and Donald H. Hesse 1

1 University of Miami School of Medicine, Coral Gables, Florida

It was found upon intravenous injection of adenosine and its mono-, di-, and triphosphate in the rat that ADP produced the greatest fall in arterial blood pressure. At low dose levels ADP was about 147 times as potent as adenosine and about 45 times as potent as AMP or ATP on an equimolar basis. The rat is more sensitive to the blood pressure lowering action of the adenosine compounds than other species thus far tested.

Note:
With the Technical Assistance of Victor Keranen

Submitted on April 27, 1961






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