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Am J Physiol 201: 1065-1067, 1961;
0002-9513/61 $5.00
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Direct adrenocortical stimulatory effect of serotonin

Arthur S. Verdesca 1, Coenraad D. Westermann 1, Richard S. Crampton 1, William C. Black 1, Relja I. Nedeljkovic 1, and James G. Hilton 1

1 Department of Medicine, St. Luke's Hospital, New York City

By means of direct arterial perfusion of the adrenal glands of the hypophysectomized dog, it was found that serotonin stimulated the secretion of hydrocortisone to a degree comparable to that seen during ACTH stimulation. Neither 5-hydroxytryptophan nor reserpine had this stimulatory effect. Physiologic mechanisms to explain the serotonin effect are discussed.

Submitted on June 5, 1961




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