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Am J Physiol 201: 1049-1052, 1961;
0002-9513/61 $5.00
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Effect of thyroid hormone on myocardial catecholamine content of the guinea pig

M. Jay Goodkind 1, David H. Fram 1, and Michael Roberts 1

1 Departments of Internal Medicine and Pharmacology, Yale University School of Medicine, New Haven, Connecticut

Normal and thyroidectomized guinea pigs were subjected to treatment with either triiodothyronine or thyroid-stimulating hormone. Determinations of myocardial catecholamine content and serum protein-bound iodine revealed a significant increase in myocardial norepinephrine content in the markedly thyrotoxic animal, and a significant decrease in norepinephrine content of the myocardium of hypothyroid animals. The significance of these findings in defining the role of catecholamines in various states of thyroid function is discussed.

Submitted on April 14, 1961






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Copyright © 1961 by the American Physiological Society.