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Am J Physiol 201: 1025-1026, 1961;
0002-9513/61 $5.00
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Extrahepatic clearance of I131 rose bengal

Don P. Jones 1, Joseph Terz 1, Walter Lawrence JR. 1, and J. William Poppell 1

1 Division of Experimental Surgery and Physiology and Andre and Bella Meyer Physiology Laboratories, Sloan-Kettering Institute for Cancer Research; and Department of Medicine, Memorial Hospital, New York City

The extrahepatic clearance of rose bengal-I131 has been measured in nine eviscerated dogs, giving a mean value of 0.33 ± .19 cc/kg-min (whole blood). The extrahepatic clearance was independent of the peripheral blood concentration of the dye over a range from 0.00038 mg/cc to 0.033 mg/cc. The error introduced in the determination of estimated hepatic blood flow due to extrahepatic extraction of rose bengal-I131 is of the order of 3.7% ± 2.8%. This error is independent of the blood concentration of the dye over the range measured.

Submitted on May 29, 1961






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