Blood content of uterus and isolated myometrium under estrogen and progesterone domination

¹ Department of Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, New York

The circulatory spaces in the whole uterus and in the isolated myometrium have been determined by comparing the amounts of hemoglobin in a weighed amount of uterine tissue with that in a known volume of blood. There is about twice as much blood in both whole uterus and isolated myometrium under progesterone domination than under estrogen domination. In addition, because of the finding that the whole uterus and the isolated myometrium contained the same amount of blood, it was concluded that the blood must be rather equally distributed in the myometrium and the endometrium. Finally, because the circulatory spaces found were within one standard deviation of the scatter of values for extracellular spaces, objective evidence was provided showing that circulatory spaces could not significantly affect distribution of electrolytes in the myometrium.