Thiocyanate space of rat brain

¹ Section on Aging, Laboratory of Psychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland

The thiocyanate space of rat brain was found to be a function of the plasma level of the ion, although, after several doses of 1–5 mm/kg sodium thiocyanate, a dynamic equilibrium was readily established and maintained between brain and plasma. Although potentially distensible, a figure of 5%, or less, is suggested for the normal volume of the extracellular compartment of rat brain.