Active reflex dilatation in the innervated perfused hind leg of the dog

¹ Department of Pharmacology, University of Michigan, Ann Arbor, Michigan

Epinephrine or norepinephrine was injected intravenously to produce reflex dilatation in the perfused hindquarters of the dog. A delay system permitted reflex effects to become maximal before arrival of the injected drug into the perfused area. Local sympathectomy of the perfused area abolishes the dilatation, thus demonstrating that the dilatation is reflex in origin. The reflex dilatation is partially active in nature because the magnitude of reflex dilatation exceeds the fall in perfusion pressure produced by sympathectomy of the perfused area. Evidence has been obtained that different sympathetic fibers mediate reflex constriction and reflex dilatation.

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