Distribution of absorbed strontium-85 and calcium-45 as influenced by lactose

¹ Department of Physical Biology, New York State Veterinary College, Cornell University, Ithaca, New York

Studies on the absorption and subsequent deposition in bone of Sr⁸⁵ and Ca⁴⁵ injected into ligated sections of small intestine of the rat showed that: a) more Ca⁴⁵ than Sr⁸⁵ was absorbed from the intestine; b) especially during the 1st 4 hr, significantly more of the absorbed Sr⁸⁵ than Ca⁴⁵ was deposited in bone; c) injection of lactose, lysine, or glucose into the ileum, along with the alkaline earths, caused the absorbed Ca⁴⁵ to deposit in the bone at the same rate as the Sr⁸⁵, and also caused an increased total absorption of both radionuclides; these observations did not hold for the duodenum or jejunum, confirming differences in mechanism among the sections of the small intestine. Tentative explanations are suggested, the most plausible one being that calcium is bound as it is absorbed from the small intestine and that the presence of lactose in the intestine inhibits the production of the bound form.

This article has been cited by other articles:

				F.J.C. Roe Relevance for Man of the Effects of Lactose, Polyols and other Carbohydrates on Calcium Metabolism Seen in Rats: A Review Human and Experimental Toxicology, March 1, 1989; 8(2): 87 - 98. [PDF]

				F.J.C. Roe and A. Bar Enzootic and Epizootic Adrenal Medullary Proliferative Disease of Rats: Influence of Dietary Factors which Affect Calcium Absorption Human and Experimental Toxicology, January 1, 1985; 4(1): 27 - 52. [Abstract] [PDF]