Effect of gallamine triethiodide and pentobarbital on certain cardiovascular and respiratory events

¹ Department of Physiology, State University of Iowa School of Medicine, Iowa City, Iowa

In dogs peripheral blood flow and blood pressure were not significantly altered during a period of 2 hours following the administration of Flaxedil. Heart rate increased significantly. Rectal temperature, hematocrit, O₂ consumption and CO₂ production were not altered. The changes in peripheral blood flow and heart rate which occur following an anesthetic dose of pentobarbital sodium were not influenced by the administration of combinations of pentobarbital and Flaxedil. Flaxedil appears to be a desirable agent to employ for controlling the muscular activity in experiments concerned with the measure of peripheral blood flow and blood pressure since this drug per se has little or no effect on these variables and thus would permit establishment of their control values. The use of this drug alone would not be permissible in painful experimental procedures.