Effect of increased portal pressure on sorption of water and sodium from the ileum of dogs

¹ Mayo Clinic and Mayo Foundation, Rochester, Minnesota

The effect of increased portal pressure on the ileal sorption of sodium and water was determined in acute studies on anesthetized dogs. Portal pressure was controlled by an inflatable cuff placed around the vein and the movement of sodium and water into and out of a segment of the ileum was determined by use of Na²² and D₂O. With the cuff in place but not inflated, exsorption of sodium (movement from blood to intestine) increased, but insorption of sodium (movement from intestine to blood) decreased, and the movement of water was little affected. Further increases in portal pressure produced a progressive increase in the rate of exsorption of sodium without having further significant effects on the insorption of sodium or the movement of water.

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				K. D. Bury, R. L. McClure, and H. K. Wright Reversal of Colonic Net Absorption to Net Secretion: With Increased Intraluminal Pressure Arch Surg, June 1, 1974; 108(6): 854 - 857. [Abstract] [PDF]