Changes in kidney enzymes of rats after birth

¹ Department of Pharmacology, Washington University School of Medicine, St. Louis, Missouri

Alkaline phosphatase, glutaminase, carbonic anhydrase and protein were measured in whole kidney homogenates of newborn, 4-, 9-, 14-, 21-, 33-, 44-, and 56-day-old rats. From birth to 21 days there is little change in glutaminase and carbonic anhydrase. At 21 days there is approximately a twofold increase. Adult levels, which are, respectively, four- and sixfold greater than at birth, were measured at 56 days. Alkaline phosphatase decreases from birth to 14 days. At 21 days newborn values are again reached and a threefold rise occurs between 21 and 33 days. Adult females had higher renal concentrations of all three enzymes than adult males.

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