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Am J Physiol 200: 313-317, 1961;
0002-9513/61 $5.00
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In vitro absorption of bile salts by small intestine of rats and guinea pigs

Leon Lack 1 and I. M. Weiner 1

1 Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University, School of Medicine, Baltimore, Maryland

The transport of taurocholic and glycocholic acids by the small intestine of rats and guinea pigs against a concentration gradient was studied by the everted gutsac technique. Transport of these substances is limited to the distal ileal segment. This transport is inhibited by anoxia, dinitrophenol and sodium azide. The system has a transport maximum. On the basis of these criteria bile acid reabsorption is considered to occur by active transport.

Submitted on September 27, 1960




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