Considerations of oxygen-hemoglobin equilibrium in the physiological state

¹ Department of Medicine, Columbia University, College of Physicians and Surgeons; and Cardio-Pulmonary Laboratory of First Medical and Chest Services, Columbia University Division, Bellevue Hospital, New York City

A formulation is presented, which applies to the oxygen-hemoglobin equilibrium under physiological conditions. This formulation fits with excellent accuracy the experimental data obtained by various authors in man and in several animal species. The marked difference in the comportment of intracellular and dilute hemoglobin is emphasized. It is indicated that Adair's four compounds hypothesis does not apply in its simplest form to intracellular hemoglobin, unless different values for different O₂ partial pressures are given to the association ‘coefficients’ and in particular to that of the fourth hemoglobin compound.

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