Glucose-induced delay in fat absorption and in appearance of Stypven clot accelerator

¹ Lilly Laboratory for Clinical Research, Marion Country General Hospital, Indianapolis, Indiana

When oleic-1-C¹⁴ acid was fed to dogs, the plasma isotope, lactescence and Stypven accelerator activity (AA) appeared simultaneously 2–4 hours after ingestion. When either peanut oil or labeled oleic acid was preceded, accompanied and followed by glucose feeding, the appearance of lactescence, AA and plasma isotope was again simultaneous but markedly delayed until 8–10 hours after fat ingestion. Serial roentgenograms of dogs given radiopaque (iodinated) peanut oil plus glucose showed that the delay in absorption of fat was not attributable to delayed gastric emptying. Although the appearance of fat in the small intestine was evident within 1–3 hours after ingestion, plasma lactescence and AA were not seen for 9–12 hours. The delay in intestinal absorption of orally ingested fat caused by glucose was also demonstrated in rats and in human subjects.