Experimental production of intra-arterial and intravenous thrombi in the rabbit and rat

¹ Harold Brunn Institute, Mount Zion Hospital and Medical Center, San Francisco, California

Small special segments of alloy wire (98% magnesium and 2% aluminum) were pretreated by immersion in 0.5% zinc chloride for 15–25 minutes. Such wires disintegrate by focal electrolysis when inserted in the aorta or inferior vena cava of rabbits or rats and in so doing cause the formation of relatively uniform white thrombi. In the artery of the rabbit such thrombi were quickly overgrown by intimal fibroblastic tissue which also penetrated each thrombus. In the artery of the rat, this reaction was much less luxuriant and slower than in the artery of the rabbit. It is emphasized that the late arterial sequel to this thrombus resembles a pearly plaque.

Note:
With the Technical Assistance of Clarence Omoto and Warren Hayashi