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Am J Physiol 199: 719-721, 1960;
0002-9513/60 $5.00
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Insulin and incorporation of radioactivity into nucleic acid fraction of isolated diaphragm

Ira G. Wool 1

1 Department of Physiology, University of Chicago, Chicago, Illinois

Insulin in vitro stimulated the incorporation into the nucleic acid fraction of isolated rat diaphragm of radioactivity from d-glucose-U-C14, adenine-8-C14 and orotic acid-6-C14; insulin had no effect on the incorporation of thymine-2-C14 into muscle nucleic acids. Insulin enhanced the incorporation into nucleic acids of C14 from adenine and orotic acid in the absence of added glucose, and incorporation of adenine-8-C14 was not influenced by glucose concentration over the range 0–600 mg %.

Submitted on March 21, 1960




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A. Gellhorn and W. Benjamin
Insulin Action in Alloxan Diabetes Modified by Actinomycin D
Science, November 27, 1964; 146(3648): 1166 - 1168.
[Abstract] [PDF]


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