Corticosteroids and accumulation of C¹⁴-labeled amino acids and histamine by isolated rat diaphragm

¹ Department of Physiology, University of Chicago, Chicago, Illinois

The rate of penetration and the magnitude of accumulation of several utilized C¹⁴-amino acids, of the amino acid analogue, -aminoisobutyric acid-1-C¹⁴, and of C¹⁴-histamine was measured in intact and cut isolated rat diaphragm. Adrenalectomy was without effect on the rate of entry of the amino acids or of histamine; cortisone administration (2 mg/day) depressed the accumulation of the utilized amino acids, of -aminoisobutyric acid and of histamine.