Incorporation of radioactive phosphate into organic phosphates of tocopherol-deficient and control rabbit muscle

¹ Radioisotope Service, Veterans Administration Hospital; Department of Medicine and Biochemistry, University of Oklahoma School of Medicine; and Biochemistry Section of Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma

Control and vitamin E-deficient rabbits were compared in their ability to incorporate intravenously injected radioactive phosphate into muscle intracellular organic phosphate. Vitamin E-deficient dystrophic muscle received inorganic phosphate from the extracellular fluid at a higher rate than did the control. Specific activity ratios showed that a smaller portion of this phosphate was converted into organic phosphate, making it appear that dystrophic muscle is less efficient than the control. Evidence is presented suggesting that at least two inorganic phosphate pools may exist in muscle cells.

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