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Am J Physiol 198: 1261-1262, 1960;
0002-9513/60 $5.00
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Effects of hypophysectomy on tissue mast cell numbers and heparin levels in the rat

L. Marx 1, C. W. Armstrong 1, P. Rucker 1, and W. Marx 1

1 Department of Biochemistry and Nutrition, School of Medicine, and Laboratories of the Allan Hancock Foundation, University of Southern California, Los Angeles, California

The effects of hypophysectomy on tissue mast cell counts and heparin concentrations were studied in male rats 1 1/2–2 months old. It was observed that removal of the pituitary gland caused a significant elevation of the mast cell numbers in liver, lung and kidney, but not in the spleen; thymus showed a trend toward increased values. The heparin contents of the organs examined were not significantly modified by the operation; the kidneys exhibited a trend toward higher values.

Submitted on January 15, 1960






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