Pulmonary venular responses to anoxia, 5-hydroxytryptamine and histamine

¹ Laboratory of Pharmacology, University of Pennsylvania Schools of Medicine, Philadelphia, Pennsylvania

In anesthetized dogs, the inhalation of 5% oxygen causes a rise in pulmonary arterial pressure but no rise in venular pressures measured by catheters with outside diameters of 0.4 mm and 1.0 mm. The venular pressure measured by the 0.4-mm catheter showed a consistent rise to 5-hydroxytryptamine. This venular constrictor response to 5-hydroxytryptamine is encountered even when pulmonary blood flow is kept constant by perfusion. The venular response to histamine is variable.

Note:
With the Assistance of Joe H. Gaskin and Severin Teufel