Effect of 1,2,4-triazole ethylamine on gastric secretion

¹ Department of Clinical Science, University of Illinois College of Medicine, Chicago, Illinois

3-(beta-aminoethylamine)-1,2,4-triazole, the triazole analogue of histamine, was found to be a potent excitant of gastric secretion, 0.42 mg of the triazole base being equivalent to 0.3 mg histamine in the dog. The action was slightly more prolonged than that of histamine. The evidence in this study along with earlier evidence strongly indicates that aminoguanidine (AG) acts additively with histamine, since AG inhibits the destruction of histamine. It was found that AG also augments the action of the triazole on gastric secretion, the mechanism of which is now uncertain.