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Am J Physiol 198: 233-236, 1960;
0002-9513/60 $5.00
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Effect of atropine and choline on urinary electrolytes

Sidney Solomon 1, Betty Jane Davis 1, and Owen Riley Boone 1

1 Department of Physiology, Medical College of Virginia, Richmond, Virginia

Single injections of atropine (0.5 mg/kg) into dogs generally caused some antidiuresis which was accompanied by a reduction in glomerular filtration rate. Atropine-induced antidiuresis may be accompanied by a fall in UNa and UCl. Atropine protected dogs against the toxic action of subsequently infused choline. In seven experiments, choline caused UpH to rise and UNa to fall. In five of seven experiments UK also fell. The action of choline on UCl is variable. At high rates of infusion, choline appears to act as an osmotic diuretic.

Submitted on July 1, 1959






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