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Am J Physiol 198: 227-229, 1960;
0002-9513/60 $5.00
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Relation of glutaminase I activity to glutamic acid concentration in the rat kidney

Leon Goldstein 1 and J. H. Copenhaver JR. 1

1 Department of Zoology, Dartmouth College, Hanover, New Hampshire

Injection of sodium glutamate had no significant effect on renal glutaminase I activity in untreated rats but suppressed the rise in enzyme activity which follows repeated ammonium chloride administration. Injection of glutamine produced a small rise in enzyme activity in untreated rats but suppressed the enzyme response in ammonium chloride-treated animals. Injection of glycine had no significant effect on enzyme activity in treated or untreated rats. A significant fall in renal glutamic acid concentration was observed 2 hours after the administration of ammonium chloride. These results suggest that there is a relation between the concentration of glutamic acid and the synthesis of glutaminase I in the kidney of the rat.

Note:
With the Technical Assistance of Walter A. Ceranski

Submitted on August 18, 1959






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