Effects of ganglionic blocking agents, pressor and depressor drugs on renal hypertension

¹ Louis D. Beaumont Memorial Research Laboratories, Mount Sinai Hospital, and the Department of Pathology, School of Medicine, Western Reserve University, Cleveland, Ohio

The effects of ganglionic blocking agents and of pressor and depressor drugs were investigated in an analysis of the humoral mechanism of renal hypertension. The pattern of response of the blood pressure to the intravenous infusion of pentolinium is suggestive of the participation of renin at various stages of experimental renal hypertension. This was reaffirmed by the effectiveness of immunologically produced antirenin in inhibiting the pressor activity of renin and in lowering the blood pressure in hypertensive animals. Apresoline, nitroglycerin and sodium azide acted identically in lowering the blood pressure of both normotensive and hypertensive dogs and were therefore unsuitable for a study of the humoral mechanism of renal hypertension. The activity of various pressor agents was enhanced to different degrees in the hypertensive dog.