| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee
The effects of desoxycorticosterone (DOC) and a new synthetic steroid-17-spirolactone (SC 8109) were determined on the functional refractory periods (F. R. P.) and transmembrane fluxes of K in isolated rabbit atria and compared with the effects of quinidine. All three agents lengthened the F. R. P., inhibited the effects of acetylcholine (ACh), terminated or prevented ACh-induced fibrillation and depressed the transmembrane efflux of K. K influx was also decreased with higher concentrations of the steroids or after a delay in time. Aldosterone and delta-1–9 alpha-flurohydrocortisone had no effect on the F. R. P. or K fluxes. It was concluded that DOC, spirolactone and quinidine act similarly as antiarrhythmic compounds by depressing Na entry.
Submitted on August 20, 1959
This article has been cited by other articles:
|
|
 |
|
  R. Caballero, I. Moreno, T. Gonzalez, C. Arias, C. Valenzuela, E. Delpon, and J. Tamargo Spironolactone and Its Main Metabolite, Canrenoic Acid, Block Human Ether-a-Go-Go-Related Gene Channels Circulation, February 18, 2003; 107(6): 889 - 895. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
