Inhibition of anaphylactoid edema in the rat by 2-deoxyglucose

¹ Department of Pharmacology, University of Texas Southwestern Medical School, Dallas, Texas

The glucose analogue 2-deoxyglucose was found to inhibit the anaphylactoid reaction of rats to dextran and ovomucoid. A dose of 200 mg/kg of 2-deoxyglucose was sufficient to antagonize the effects of 60 mg/kg of dextran or 10 mg/kg of ovomucoid when these compounds were injected by the intravenous route. The reaction of rats to compound 48/80 was not inhibited. In rats pretreated with insulin larger doses of 2-deoxyglucose were required to obtain the same inhibition of anaphylactoid edema. These results and the previously demonstrated effects of insulin point to an important role of glucose permeability in certain inflammatory processes.

Note:
With the Technical Assistance of Mary Knoohuizen