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Am J Physiol 197: 808-812, 1959;
0002-9513/59 $5.00
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Nerve fiber activity in heavy water

C. S. Spyropoulos 1 and M. E. Ezzy 1

1 Laboratory of Neurophysiology, National Institutes of Health, Bethesda, Maryland

Replacement of normal Ringer's surrounding the node of Ranvier of Bufo marinus with Ringer's prepared with D2O instead of H2O resulted in an increase in the duration of the response. In the squid giant axon immersed in D2O a rise in threshold membrane potential and a prolongation of the spike potential were observed.

Submitted on June 5, 1959







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Copyright © 1959 by the American Physiological Society.