Localization and retention of triolein I¹³¹ in various tissues of the atherosclerotic rabbit

¹ Harold Brunn Institute and Department of Radiology, Mount Zion Hospital and Medical Center, San Francisco, California

The rate of disappearance of intravenously injected triolein I¹³¹ from the blood stream and its concentration in various tissues were studied both in the normal and in the atherosclerotic rabbit. No difference in the rate of disappearance of the I¹³¹ from blood was observed between the normal and atherosclerotic rabbit. The atherosclerotic aorta was observed to take up approximately twice as much I¹³¹ as normal aorta when the tissues were assayed 10 minutes after injection. However, 24 hours after injection no essential difference was observed. All other tissues examined (fat, adrenal, spleen and liver) were observed to take up and retain more I¹³¹ than either the normal or the atherosclerotic aorta. The results suggest that the atherosclerotic aorta of the rabbit, while taking up initially more I¹³¹ than the normal aorta, appears to metabolize or otherwise rid itself of such I¹³¹ as rapidly as the latter in a period of 24 hours.

Note:
With the Technical Assistance of Veronica Mena