Effects of iodoacetate on potassium, glucose and lactic acid metabolism in isolated perfused frog liver

¹ Department of Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York

Iodoacetate (IAA) caused a decreased lactic acid production and increased glucose and potassium losses in the isolated perfused frog liver. These effects of IAA are compared to those of epinephrine which increased lactic acid production as well as causing glucose and potassium losses. Interpretation of these results is based on the assumption that both agents will cause an increase in the concentration of hexosemonophosphates, an event which may be associated with potassium loss from the liver.