Daily output of pancreatic juice and some dietary factors which influence it

¹ Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington

Evidence is presented that the chronic pancreatic fistula dogs can be used effectively to study pancreatic physiology on a daily output basis. By increasing the amount of a mixed diet fed or by adding fat to the diet the volume and protease and lipase activities can be increased. Additions of cellulose, milk, casein hydrolysate were ineffective. On the basal mixed diet neither volume, amylase nor protease increased independently of each other. Changes in one enzyme activity without the other or in volume without enzymes were seen with supplements of essential amino acids or soy flour. The possible mechanism of these effects is discussed.