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Am J Physiol 197: 138-140, 1959;
0002-9513/59 $5.00
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Metabolism of glutamic acid in the perfused rabbit heart

Ruth G. Doell 1 and James M. Felts 1

1 Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts

The metabolism of C14-labeled glutamic acid by the isolated perfused heart was studied. Glutamic acid is readily assimilated by the normally beating heart and in the course of an hour's perfusion about 22% is oxidized to C14O2. Approximately 3.6% of the administered radioactivity is converted to glutamine. The utilization of glucose by the preparation is variable and not correlated with the concentration of glucose in the perfusate.

Submitted on February 15, 1959






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