Influence of androgens on the transaminases and glutamic dehydrogenase of tissues

¹ University of Alabama Medical Center, Birmingham, Alabama and Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma

Aspartic-glutamic and alanine-glutamic transaminase activities of the kidney and heart of the rat and mouse change in direct proportion with the changes in weight produced by castration and testosterone. The transaminase activities of the rat but not the mouse liver are decreased by castration and restored to normal by testosterone propionate administration. The glutamic dehydrogenase activity of the liver and kidney of the rat and the mouse is not altered by castration or androgen administration. An increase of the kidney weight above normal size by androgen, however, is accompanied by a proportionate increase in the enzyme.