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Am J Physiol 197: 102-104, 1959;
0002-9513/59 $5.00
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Effect of ß-sitosterol on serum cholesterol concentration in the rat

Narindar Nath 1 and A. E. Harper 1

1 Department of Biochemistry, University of Wisconsin, Madison, Wisconsin

ß-Sitosterol added to a diet containing cholesterol alone or with cholic acid, diminished the accumulation of serum and liver cholesterol in the rat. This effect depended upon the quantity of ß-sitosterol added. Addition of ß-sitosterol to a diet containing corn oil enhanced the hypocholesteremic effect of corn oil. Calciferol and Q275 when fed to rats had no significant effect on serum cholesterol concentration, but calciferol caused an increase in the deposition of cholesterol in the liver.

Submitted on October 29, 1958






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