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Am J Physiol 196: 981-982, 1959;
0002-9513/59 $5.00
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Augmentation of mouse thyroid iodide pump activity after withdrawal of propylthiouracil

H. J. Lipner 1, Billie P. Wagner 1, and Harold P. Morris 1

1 Division of Physiology, Florida State University, Tallahassee, Florida, and Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland

The chronic administration of propylthiouracil for 16–30 days to mice resulted in either no increase or depression in the specific activity of the thyroid iodide pump. Within 24 hours after the withdrawal of propylthiouracil from the diet there occurred an augmentation of the specific activity of the iodide pump. The total activity of the thyroid pump behaved in a similar manner. The disassociation of pump activity from growth suggests that in the mouse these parameters of thyroid function are independent processes.

Submitted on December 4, 1958






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