Comparison of external loss of sodium with loss from sucrose space in adrenalectomized rats

¹ Department of Physiology, Washington University School of Medicine, St. Louis, Missouri

Using 1-hour sucrose space in rats as a measure of extracellular fluid (ECF) volume, net loss of Na from ECF is found to agree closely with external loss (balance data) 6 days after adrenalectomy. No significant exchange of Na between ECF and intact cells is evident following adrenalectomy. Fair correspondence of net loss of Na from ECF with external loss was also seen in normal rats mildly depleted of Na by 6 days on an essentially Na-free diet. Sucrose space (ml/kg final weight) is 225 ± 12 in normal rats, 197 ± 13 in adrenalectomized, and 209 ± 9 in normal rats after 6 days on an essentially Na-free diet. Evidence is presented that sucrose space measure a reproducible ECF compartment in normal, adrenalectomized and salt-depleted rats.

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