Effect of acetazoleamide alone and during asphyxia on hippocampal and cortical activity in the marsupial phalanger

¹ Department of Anatomy, University of Melbourne, Victoria, Australia

The effects of asphyxia and acetazoleamide on evoked hippocampal and cortical activity in the marsupial phalanger were determined. During asphyxia the evoked hippocampal activity was affected before the evoked cortical activity. Acetazoleamide administered prior to asphyxia caused inhibition earlier during asphyxia and prolonged the recovery period of the evoked activity in both regions. Acetazoleamide gave only slight protection in the hippocampus against electrically induced seizures. The peak effect of the drug was reached 4 hours after administration and then declined gradually.