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Am J Physiol 196: 1003-1004, 1959;
0002-9513/59 $5.00
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Effect of reserpine on excitability of the turtle heart

Edward Stein 1, John Magin 1, and Morris Kleinfeld 1

1 Department of Medicine, New York University College of Medicine, and Electrocardiographic Laboratory of the Third (N. Y. U.) Medical Division of Bellevue Hospital, New York City

The effects of reserpine on the cardiac excitability of the atrium and ventricle were studied in the turtle. Reserpine in concentrations of 0.5 and 1.0 mg/kg was found to have a quinidine-like action on cardiac excitability. This was manifested by a prolongation of latency, an increase in duration of the absolute and relative refractory periods and an elevation of diastolic threshold. When compared to quinidine in similar dosage, reserpine was appreciably less active.

Submitted on November 23, 1958






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