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Am J Physiol 196: 857-858, 1959;
0002-9513/59 $5.00
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Effect of tetraiodothyroformic acid on oxygen consumption of the cholesterol-thiouracil-fed rat

Maurice M. Best 1 and Charles H. Duncan 1

1 Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky

The formic acid analogue of thyroxine, tetraiodothyroformic acid, was found to have 0.086% the goiter inhibiting activity of l-thyroxine in the thiouracil-cholesterol-fed rat. With regard to oxygen consumption its activity was 0.084% that of l-thyroxine. In amounts having equal effect on thyroid weight and oxygen consumption, tetraiodothyroformic acid resulted in significantly lower mean liver cholesterol.

Submitted on August 8, 1958




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