Mechanism of gastric hypersecretion following portacaval transposition

¹ Department of Surgery, University of Chicago, Chicago, Illinois

Dogs were prepared with vagus denervated total stomach pouches and with isolated vagus denervated Heidenhain and antrum pouches. Under these conditions the nervous phase of gastric secretion is excluded, and since the antrum does not come in contact with food, its activity in the release of gastrin is minimal. Nevertheless, portacaval transposition produced a marked augmentation of gastric secretion, presumably because some gastric secretory hormone or secretagogue elaborated by the intestines escapes inactivation or excretion by the liver.

Note:
With the Technical Assistance of Donald R. Thursh and Richard A. Weinberg