Effect of various psychotomimetic drugs on rate of appearance of carbon-14 in the brains of mice after administration of C¹⁴ glucose

¹ Department of Pharmacology, The Upjohn Company, Kalamazoo, Michigan

The psychotomimetic drugs, bulbocapnine, bufotenine, mescaline, N-methyl-3-piperidyl benzilate, as well as physostigmine and chlorpromazine, decreased the rate of appearance of radioactivity in the brains of mice after either i.v. or i.p. injection of C¹⁴ glucose. LSD·25 behaved similarly but the effects were somewhat variable. Atropine, phenobarbital, meprobamate (Miltown), pipradol hydrochloride (Meratran), methylphenidate (Ritalin), hydroxyzine hydrochloride (Atarax), iproniazid and adrenolutin had little or no inhibitory effect. Atropine and amphetamine reversed the inhibitory effects of physostigmine but not of other drugs tested. The psychotomimetic drugs as well as chlorpromazine inhibited pseudo cholinesterase. The possibility that the inhibition of transport is related to inhibition of this enzyme is discussed.